Neurobiology of Disease Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration
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چکیده
Qiang Liu,1 Justin Trotter,6 Juan Zhang,1 Melinda M. Peters,6 Hua Cheng,2 Jianxin Bao,3 Xianlin Han,2 Edwin J. Weeber,6 and Guojun Bu1,4,5 Departments of 1Pediatrics, 2Medicine, 3Otolaryngology, and 4Cell Biology and Physiology, 5Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, and 6Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida 33612
منابع مشابه
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.
The vast majority of Alzheimer's disease (AD) cases are late onset with progressive synapse loss and neurodegeneration. Although the amyloid hypothesis has generated great insights into the disease mechanism, several lines of evidence indicate that other risk factors might precondition the brain to amyloid toxicity. Here, we show that the deletion of a major lipoprotein receptor, low-density li...
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Alzheimer's disease (AD) is a neurological disorder characterized by profound memory loss and progressive dementia. Accumulating evidence suggests that Type 2 diabetes mellitus, a metabolic disorder characterized by insulin resistance and glucose intolerance, significantly increases the risk for developing AD. Whereas amyloid-β (Aβ) deposition and neurofibrillary tangles are major histological ...
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تاریخ انتشار 2010